Keystone
First Strike
When you initiate champion combat, deal 7% extra damage for 3 seconds and gain gold based on damage dealt.
Rune Effect
Cooldown: 25 - 15s
Position in the Tree
Alternatives in the same row — picking First Strike means giving these up:
Best Champions With First Strike
From real ranked build data — win rate and games refer to the champion's build that includes First Strike.
Builds Featuring First Strike
About First Strike
In League of Legends, First Strike sits in the Inspiration tree as a keystone — the defining rune of a page. Its effect: When you initiate champion combat, deal 7% extra damage for 3 seconds and gain gold based on damage dealt. In the current patch it appears in real ranked builds for Syndra, Zed, Miss Fortune and 5 more champions — Syndra’s Mid build runs it at a 50.9% win rate across 289,903 games.
When picking it you give up Glacial Augment and Unsealed Spellbook from the same row, so the choice depends on your champion and matchup. Rune data comes from Riot’s Data Dragon (version 16.14.1) and champion usage is based on real ranked statistics, refreshed automatically.
First Strike — Rune Questions
When you initiate champion combat, deal 7% extra damage for 3 seconds and gain gold based on damage dealt.
First Strike is part of the Inspiration tree as one of its keystones.
Yes — it sits in the keystone slot of Inspiration and defines the identity of the rune page.
Miss Fortune, Syndra, Zed, Kha'Zix, Qiyana and 3 more champions run it in current ranked builds — every build is linked above.