Latest Cassiopeia build for League of Legends with items, runes, summoner spells, skill order, counters and patch data.
Cassiopeia’s mid lane numbers read 48.88% winrate at a 1.4% pick rate on patch 16.13.1, a demanding pick per current ranked data, though top lane is listed as a secondary option for those willing to adapt. Deathfire Touch is her keystone, adding damage over time to her poison-stacking combos.
Skill order runs E first, then Q, then W, prioritizing twin fang’s poison application. Tear of the Goddess, Rod of Ages, and Seraph’s Embrace make up her core, a mana-scaling build that grows her damage and bulk together. See the complete item order, runes, and counters below.
Imported from op.gg · updated every 48 hours · last update Jul 16, 2026.
Deathfire Touch
Manaflow Band
Transcendence
Scorch
Presence of Mind
Coup de Grace
Adaptive Force
Adaptive Force
Health Scaling
Flash
Teleport
Levels shown as recorded in ranked data; R is highlighted at its level-up points.
Deathfire Touch
Manaflow Band
Transcendence
Scorch
Presence of Mind
Coup de Grace
Adaptive Force
Adaptive Force
Health Scaling
Flash
Ghost
Levels shown as recorded in ranked data; R is highlighted at its level-up points.
Win rates are Cassiopeia's results against each champion, imported from op.gg.
Based on current ranked data (op.gg, patch 16.13.1), the strongest recorded Cassiopeia build in Middle goes Tear of the Goddess, Rod of Ages, Seraph's Embrace, Rylai's Crystal Scepter as core items, with a 48.12% win rate across 3,456 games.
The most played rune page runs Deathfire Touch (Sorcery) with Precision as the secondary tree.
Tear of the Goddess, Rod of Ages, Seraph's Embrace, Rylai's Crystal Scepter.
Based on real matchup data, Cassiopeia struggles most against Locke, Syndra, Yasuo.
Build and counter data is refreshed automatically every 48 hours from ranked game statistics.