Vayne vs Karthus Counter Pick
Matchup Summary
What the Data Means
How does Vayne really do against Karthus in ADC? The numbers below come from live ranked matchup data. Across 214 recorded games on patch 16.13.1, Vayne wins 56.1% of the time against Karthus. That puts the matchup in Vayne’s favor — the win rate sits above break-even, making Karthus one of the targets Vayne punishes most reliably.
Win rate and sample size are the two numbers to trust here: the more games behind a matchup, the more stable its rating from patch to patch. The stats refresh automatically every 48 hours from ranked games at Emerald and above, so this page always reflects the current meta rather than an old snapshot. For itemization and runes, open the current Vayne build; both champions’ full profiles and remaining matchups are linked below.
FAQ
Yes — Vayne holds the statistical advantage in this matchup. Vayne wins 56.1% of the recorded games.
56.1% from Vayne's perspective, measured on patch 16.13.1.
214 ranked games at Emerald rank and above, across all regions.
The current Vayne build — items, runes and skill order from the same data set — is on the Vayne build page.